Schedule

Sunday, April 4th – Registration

Registration

Monday, April 5th – Welcome

Registration Continues

Introduction & Welcome

By Kurt Hankenson, University of Michigan, AIMM President

Monday, April 5th – Session 1

PTH Action in Bone: “Back To The Future”

Chair: Larry Suva, Texas A&M

The NACA transcriptional coregulator is an effector of PTH anabolism

By René St. Arnaud, McGill University and Shriners Hospital

Salt inducible kinases dictate Pth1r action in bone and mineral metabolism

By Marc Wein, Harvard University

Break

8:50AM – 9:00AM

Effects of standard versus high dose PTH in combination with denosumab on bone microarchitecture

By John Haddad Young Investigator: Sabashini Ramchand, Harvard – MGH

Intermittent Parathyroid Hormone Treatment Reduces Marrow Adipose Tissue In Patients with Hypoparathyroidism

By John Haddad Young Investigator: Annegreet Veldhuis-Vlug, Leiden University Med Center

Mid-day Break

Meet the Young Investigators

Meet the Professor Break-Out 1: Non-rodent animal models to study the skeleton

By Dana Gaddy,Texas A&M

Meet the Professor Break Out 2: Heterotopic ossification – how does bone form outside of the skeleton?

By Eileen Shore, University of Pennsylvania

Meet – and – Greet (for in-person attendees)

Tuesday, April 6th – Session 2

Cutting Edge Genetics in Diagnosis and Treatment of Musculoskeletal Disease

Chair: Suzanne Jan de Beur, Johns Hopkins

Application of New Genetic Technologies in the Clinic

By Ingrid Holm, Boston Children’s Hospital

The Latest in Skeletal Dysplasias: Genetics, Phenotyping and Treatment

By Julie Hoover-Fong, Johns Hopkins

Break

8:50AM – 9:00AM

Frizzled 2 and Craniofacial Bone Development: A Tale of Two Mouse Models

By John Haddad Young Investigator: Megan Michalski, Van Andel Institute

Identifying Targets for Osteoporosis via Whole Exome Sequencing and CRISPR-Cas9

By John Haddad Young Investigator: Sirui Zhou, Lady Davis Institute of Jewish General Hospital

Origin and Functions of Osteoclasts and Macrophages in Inflammatory Arthritis

By John Haddad Young Investigator: Christian Jacome-Galarza, Brigham and Women’s Hospital

Mid-day Break

Young Investigator Mentoring Sessions – Break Out

Meet the Professor Break-Out 1: Controversies in pharmaceutical treatment of patients with achondroplasia

By Julie Hoover-Fong, Johns Hopkins

Meet the Professor Break Out 2: Career development: Starting your new
lab

By Joy Wu, Stanford University

Courtney Karner, University of Texas Southwestern

Wednesday, April 7th – Session 3

Novel therapies to target the bone marrow niche in cancer

Co-Chairs:

Melissa Kacena, Indiana University

Jesús Delgado-Calle, University of Arkansas Medical School

Osteocytes and the bone/bone marrow niche of cancer in bone

By Terestia Bellido, University of Arkansas Medical School

PTH actions in the breast cancer bone metastatic niche

By Joy Wu, Stanford University

Break

8:50AM – 9:00AM

Remodeling our perspective on osteocytes: the link between bone and energy homeostasis

By John Haddad Young Investigator: Neha Dole, University of California, San Francisco

Osteocyte-specific deletion of the auxiliary α2δ1 voltage sensitive calcium channel subunitimpairs femur strength and load-induced bone formation

By Charles H. Turner Young Investigator: Christian Wright, Indiana University

Influence of Genetic Variability on Musculoskeletal Response to Unloading in Diversity Outbred Mouse Founder Strains

By AIMM Investigator: Michael Friedman, Virginia Commonwealth University

Mid-day Break

Business Meeting

Workshop: NIH initiatives to promote diversity in science

By Kristy Nicks, NIH – NIAMS

Thursday, April 8th – Session 4

Fracture repair, a model of regeneration: evolving concepts

Chair: Dan Bikle, University of California, San Francisco

Fracture Nonunion: New Insights into Mechanism and Therapy

By Jie Shen, Washington University

Life, Death and Transformation in the Transition Zone: an Emerging Model of Endochondral Ossification

By Ralph Marcucio, University of California, San Francisco

Break

8:50AM – 9:00AM

From fish to fractures: Translational biology of Notch signaling

By John Haddad Young Investigator: Daniel Youngstrom, University of Connecticut Health Center

The stem cell basis of bone versus fat formation

By John Haddad Young Investigator: Shawon Debnath, Weill Cornell Medical College

Mid-day Break

Young Investigator Break Out Rooms – Scientific Discussions

Meet the Professor Session 1: Management of low bone density in functional hypothalamic amenorrhea

By Madhu Misra, Harvard

Meet the Professor Session 2: How to use the versatility of a FACS machine for bone and mineral research”

By Matthew Greenblatt, Weill Cornell Medical College

Friday, April 9th – Session 5

Neuropsychiatric disorders and medications: Impact on bone

Chair: Tamara King, University of New England

Dances with bones: inter-tissue communication in the regulation of long bone growth

By John Haddad Young Investigator: Alberto Rosello-Diez, Monash University

Impact of autism spectrum disorder and anorexia nervosa on bone in adolescents and young adults”

By Madhu Misra, Harvard

Break

8:30AM – 8:40AM

Atypical antipsychotic drug effects on bone and metabolism: new insights after warming up the mice

By Katie Motyl, Maine Medical Research Center Institute (MMCRI)

Vitamin D receptor signaling prevents the adverse actions of glucocorticoid excess in bone, skeletal muscle, and the heart, by interfering with the atrogene pathway

By John Haddad Young Investigator: Amy Sato, University of Arkansas Medical Center

Mid-day Break

Strategic Planning Discussions